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Your Heart on GLP-1s: Why Cardiologists Are Paying Attention

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This is probably one of the more exciting conversations happening in medicine right now. And I don't say that lightly. Today, I want to go deep on one specific area where GLP-1s have some of the strongest data available right now, and that is heart and lipid protection. Let's talk about what that actually looks like, especially because we're still in American Heart Month . I want you to remember that more than 650,000 Americans die from heart disease every year so this is the one that honestly gets me the most fired up. Because we know that GLP-1 receptors are in blood vessels and in the heart. They are physically located there. So when we activate them, we're not just helping you lose weight. We are directly supporting cardiovascular function. What GLP-1s Do Inside Your Blood Vessels Because GLP-1 receptors live in the blood vessels and in the heart, when we signal them properly, a few really important things happen. The inside lining of those blood vessels, what we c...
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GLP-1s Are Not Just for Weight Loss Anymore

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And honestly, that's the part nobody's really talking about. We're going to dive into GLP-1s, but not the way you've been hearing about them. We're going beyond weight loss. Because saying GLP-1s are just for weight loss is kind of like saying a smartphone is just for making phone calls. It really has so many things that it signals on a regular basis. In the podcast, I briefly mentioned the SELECT Trial, but I want to slow down for a moment and give you a little more context because this study truly changed the conversation around GLP-1 medications. In 2023, the SELECT Trial (published in the New England Journal of Medicine https://www.nejm.org/doi/full/10.1056/NEJMoa2307563 ) followed more than 17,000 adults who were overweight or obese and had established cardiovascular disease, but importantly, they did not have diabetes. Participants were given semaglutide at the 2.4 mg dose (the dose used for weight management) and were followed for several years. What researc...
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Why the FDA (Food and Drug Administration) Finally Removed the Blackbox Warning on Estradiol

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  After 20+ Years, the FDA Finally Admitted What We've Known All Along This is huge. For over two decades, estrogen carried a black box warning—the FDA's strongest safety warning—that scared women away from treatment. It shaped medical practice across the country. It created widespread fear. It kept millions of women suffering unnecessarily. And the truth is, this fear was based on flawed data all along. The FDA finally removed the black box warning on estradiol in 2024. And it's one of the most important shifts in women's health in a generation. Let's talk about why this finally happened, what it means for women right now, and why it took so damn long. The WHI Study Never Deserved a Black Box Warning in the First Place The entire reason estrogen was labeled dangerous comes back to one study: the Women's Health Initiative (WHI) from 2002. And that study was fundamentally flawed from the beginning. "The Women's Health Initiative study was flawed." L...
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